Hotels in Panacea

September 2026
12
October 2026

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Sep 18 - Sep 20
In two weeks
Sep 25 - Sep 27

Where to stay in Panacea?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Panacea on Hotels.com. These Panacea hotels consistently deliver on quality, location and traveler experience. Last updated on September 12, 2026.

1. Hyatt House Tallahassee Capitol – University

Hyatt House Tallahassee Capitol – University
Railroad Square Art District
¥18,126
¥20,392 total
includes taxes & fees
Oct 5 - Oct 6
Hyatt House Tallahassee Capitol – University

2. The Panacea Motel

The Panacea Motel
Panacea
¥17,569
¥19,589 total
includes taxes & fees
Sep 13 - Sep 14
The Panacea Motel

3. BOB Hotels Tallahassee - Boutique on Budget

BOB Hotels Tallahassee - Boutique on Budget
Tallahassee
¥7,237
¥9,376 total
includes taxes & fees
Sep 22 - Sep 23
BOB Hotels Tallahassee - Boutique on Budget

4. Four Points by Sheraton Tallahassee Downtown

Four Points by Sheraton Tallahassee Downtown
Governor's Walk
¥16,086
¥18,096 total
includes taxes & fees
Sep 13 - Sep 14
Four Points by Sheraton Tallahassee Downtown

5. Hotel Indigo Tallahassee - Collegetown by IHG

Hotel Indigo Tallahassee - Collegetown by IHG
College Town
¥20,584
¥23,157 total
includes taxes & fees
Oct 11 - Oct 12
Hotel Indigo Tallahassee - Collegetown by IHG

6. The Lodge at Wakulla Springs

The Lodge at Wakulla Springs
Crawfordville
¥12,952
¥14,441 total
includes taxes & fees
Sep 16 - Sep 17
The Lodge at Wakulla Springs

7. Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville
¥17,081
¥19,046 total
includes taxes & fees
Oct 11 - Oct 12
Best Western Wakulla Inn & Suites

8. Wildwood Inn

Wildwood Inn
Crawfordville
¥18,091
¥20,785 total
includes taxes & fees
Oct 11 - Oct 12
Wildwood Inn

9. St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle
¥15,213
¥22,405 total
includes taxes & fees
Sep 13 - Sep 14
St James Bay Golf & Pickleball Resort

10. Home2 Suites by Hilton Tallahassee State Capitol

Home2 Suites by Hilton Tallahassee State Capitol
Tallahassee
¥17,508
¥19,698 total
includes taxes & fees
Oct 12 - Oct 13
Home2 Suites by Hilton Tallahassee State Capitol

11. Courtyard by Marriott Tallahassee Downtown/Capitol

Courtyard by Marriott Tallahassee Downtown/Capitol
Tallahassee
¥12,166
¥13,686 total
includes taxes & fees
Oct 11 - Oct 12
Courtyard by Marriott Tallahassee Downtown/Capitol

12. Aloft by Marriott Tallahassee Downtown

Aloft by Marriott Tallahassee Downtown
Capitol Hill
¥17,925
¥20,166 total
includes taxes & fees
Sep 27 - Sep 28
Aloft by Marriott Tallahassee Downtown

13. stayAPT Suites Tallahassee-Capitol

stayAPT Suites Tallahassee-Capitol
Tallahassee
¥15,404
¥17,329 total
includes taxes & fees
Sep 23 - Sep 24
stayAPT Suites Tallahassee-Capitol

14. Fairfield Inn & Suites by Marriott Tallahassee Central

Fairfield Inn & Suites by Marriott Tallahassee Central
Tallahassee
¥14,885
¥16,745 total
includes taxes & fees
Oct 4 - Oct 5
Fairfield Inn & Suites by Marriott Tallahassee Central

15. DoubleTree by Hilton Hotel Tallahassee

DoubleTree by Hilton Hotel Tallahassee
Capitol Hill
¥17,597
¥19,797 total
includes taxes & fees
Sep 20 - Sep 21
DoubleTree by Hilton Hotel Tallahassee

16. Holiday Inn Tallahassee E Capitol - Univ by IHG

Holiday Inn Tallahassee E Capitol - Univ by IHG
Tallahassee
¥16,829
¥18,933 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Tallahassee E Capitol - Univ by IHG

17. The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle
¥17,925
¥19,807 total
includes taxes & fees
Sep 24 - Sep 25
The Old Carrabelle Hotel

18. Hampton Inn & Suites Tallahassee Capitol - University

Hampton Inn & Suites Tallahassee Capitol - University
Railroad Square Art District
¥17,508
¥19,697 total
includes taxes & fees
Oct 11 - Oct 12
Hampton Inn & Suites Tallahassee Capitol - University

19. Hilton Garden Inn Tallahassee Central

Hilton Garden Inn Tallahassee Central
Tallahassee
¥16,249
¥18,280 total
includes taxes & fees
Oct 4 - Oct 5
Hilton Garden Inn Tallahassee Central

20. Hotel Duval, Autograph Collection

Hotel Duval, Autograph Collection
Governor's Walk
¥20,272
¥22,806 total
includes taxes & fees
Oct 12 - Oct 13
Hotel Duval, Autograph Collection
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Go beyond your typical stay in Panacea

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Our prices for hotels in Panacea are cheapest in February

Price trends for hotels in Panacea

Pricing is based on two traveler single night rates
View properties in September

September

High 30°C / low 23°C. Sunny most days.
30°
23°
27°
18°
22°
13°
19°
11°
17°
19°
10°
22°
13°
25°
16°
29°
20°
31°
23°
32°
24°
32°
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Monthly weather averages (˚C)

Top landmarks in Panacea

Alligator Point Beach

8.8/10 (10 reviews)
When the beach is calling your name, you might want to head down to Alligator Point Beach, located 4.5 mi (7.2 km) from central Alligator Point. Enjoy the sunset by the shore at Wilson Beach.
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Bald Point State Park

8.6/10 (20 reviews)
Bald Point State Park is 1.7 mi (2.7 km) from central Alligator Point, why not stop by during your stay.
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Mashes Sand Beach

8.8/10 (3 reviews)
If being by the water is a major draw, Mashes Sand Beach is a spot you might want to check out, located 5.1 mi (8.2 km) from central Panacea. If you want to continue walking by the waves, head to Shell Point Beach, Wilson Beach, and Alligator Point Beach.
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Wilson Beach

Whether you want to collect beach glass or watch the sunset, Wilson Beach is a spot you might want to check out, located 7.4 mi (11.9 km) from central Panacea. Enjoy the sunset by the shore at Alligator Point Beach.
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beach near Alligator Point

When the beach is calling your name, you might want to head down to beach near Alligator Point, located 2.7 mi (4.4 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
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beach near Summer Camp Beach

Whether you want to collect beach glass or watch the sunset, beach near Summer Camp Beach is a spot you might want to check out, located 10.3 mi (16.6 km) from central Panacea. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
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Public Beach Access

Public Beach Access is 2.3 mi (3.7 km) from central Alligator Point, why not stop by during your stay. Want to stretch your legs some more? Head to Alligator Harbor Aquatic Preserve, located nearby.
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beach near Lighthouse Point

If you can't wait to get to the beach, you might enjoy a trip to beach near Lighthouse Point located 1.7 mi (2.7 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach, Mashes Sand Beach, and Wilson Beach.
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Learn more about Panacea

Notable for its natural beauty, Panacea features attractions such as Mashes Sand Beach and Alligator Point Beach. This beachside city has something for everyone including seafood restaurants as well as sights like Bald Point State Park and Wilson Beach. All are within a secluded setting.

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A sunset over a calm body of water with silhouettes of birds flying and a distant tree line.

Check out reviews of Panacea hotels guests love

The Panacea Motel

The Panacea Motel
Panacea

10/10 Exceptional

United States
Holly
The Panacea Motel

Wildwood Inn

Wildwood Inn
Crawfordville

10/10 Exceptional

United States
Marilou
Wildwood Inn

Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville

10/10 Exceptional

United States
Paul
Best Western Wakulla Inn & Suites

St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle

10/10 Exceptional

United States
Nancy
St James Bay Golf & Pickleball Resort

The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle

10/10 Exceptional

United States
Patty
The Old Carrabelle Hotel

Franklin Inn

Franklin Inn
Carrabelle

10/10 Exceptional

United States
Marla
Franklin Inn

The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle

10/10 Exceptional

United States
Tuledo
The Moorings Hotel and Marina

Find out more about Panacea

Panacea Unveiled: Where Sandy Shores Embrace Untamed Nature

Nestled along Florida's stunning coastline, Panacea is a hidden gem for nature enthusiasts and beach lovers alike. This charming small town boasts serene beaches and lush wetlands, making it perfect for kayaking, fishing, and birdwatching. Explore the nearby Panacea Springs, renowned for its natural beauty, and immerse yourself in the tranquility of the Apalachicola National Forest. Whether you’re savoring fresh seafood at local eateries or strolling along the picturesque shores, Panacea offers a peaceful retreat where you can unwind and connect with nature. Discover the essence of Florida’s coastal charm in this delightful off-the-beaten-path destination. For great hotel rates in Panacea, be sure to check out Hotels.com's Last-Minute Dealsopens in new window on travel.

Discover great hotels near Panacea

Panacea offers a variety of hotel styles, from cozy motels to modern hotels, many with competitive room rates and flexible cancellation options. Travelers can find options that suit different budgets and preferences, including cheap choices and higher-end accommodations. Here are some of the most popular hotels with our travelers near Panacea:

  1. Best Western Wakulla Inn & Suitesopens in new window: This 3-star gem boasts an impressive guest rating of 8.8, offering a mix of adventure sports and upscale leisure amenities. It promises an experience filled with curated adventures, from nearby sailing and snorkeling to scenic hiking and kayaking. The atmosphere is tailored for leisure travelers seeking a blend of comfort and exploration, enhanced by features like express check-in and thoughtfully designed spaces. The ambiance is elevated with a focus on high-quality, boutique experiences that ensure a smooth, delightful stay.
  2. Wildwood Innopens in new window: With a comfortable 3.0-star rating and a guest rating of 8.6, this hotel is a refined choice for leisure travelers who value a well-rounded experience. Guests will appreciate the curated adventure sports including boat tours and mountain biking, complemented by amenities such as high-end dining options and express check-in services. The property is designed to offer a seamless experience with emphasis on cleanliness and efficiency, making it a solid pick for those seeking distinctive and stylish stays.
  3. St James Bay Golf & Pickleball Resortopens in new window: This 3.5-star property shines with a guest rating of 9.0, offering a sophisticated retreat for leisure travelers with a passion for curated experiences. Guests can indulge in activities like golf and parasailing, while enjoying the comforts of thoughtfully designed spaces, high-end dining, and express check-in. The property exudes a boutique charm with architectural elegance and an atmosphere that promises a high-quality, memorable stay in an environment crafted for relaxation and distinctive adventures.

Where to stay in and around Panacea

In Saint Teresa, Alligator Point, Crawfordville, each area offers its own appeal: Saint Teresa is emerging with local charm, Alligator Point offers a unique coastal vibe, and Crawfordville is ideal for nature lovers and families with its hiking, boating, and dining options. For first-time visitors, Crawfordville is best suited for an accessible and relaxed stay.

  1. Saint Teresaopens in new window: Saint Teresa is a charming coastal destination perfect for those seeking a tranquil getaway. Nestled near the Gulf of Mexico, it offers stunning views and a relaxing atmosphere ideal for unwinding. The nearby beaches are great for sunbathing and exploring nature, making it a favorite among families and nature lovers. Enjoy peaceful walks along the shoreline or take part in bird watching, as the area is home to diverse wildlife. With cozy accommodations available, you’ll find it easy to settle in and enjoy the scenic beauty of this hidden gem.
  2. Alligator Pointopens in new window: Alligator Point is a serene spot known for its beautiful beaches and picturesque landscapes. This laid-back locale is perfect for boating enthusiasts and those who enjoy fishing, offering easy access to the water. The natural surroundings provide excellent opportunities for hiking and wildlife observation. If you’re looking to escape the hustle and bustle, Alligator Point’s friendly community and relaxed vibe create an inviting atmosphere for visitors. It's an ideal base for exploring nearby natural attractions while enjoying peaceful beach days.
  3. Crawfordvilleopens in new window: Crawfordville is a delightful area rich in natural beauty and outdoor activities. With its lush forests and wildlife, it’s perfect for hiking and exploring nature trails. Family-friendly parks and recreational areas make it a great choice for a fun day out with loved ones. You can also enjoy the local dining scene, which features a variety of options to satisfy your cravings after a day of adventure. Crawfordville's friendly people and welcoming atmosphere make it a wonderful place to relax and immerse yourself in Florida’s natural wonders.

Things to do in Panacea

Panacea is a traveler's delight with pristine beaches, verdant forests, and stunning sunsets. Enjoy boating, sea diving, and wildlife spotting while staying at comfortable local hotels. It’s a nature lover’s haven that promises memorable experiences and relaxing days on the water.

  • Shell Point Beachopens in new window – Relax on the soft sand and enjoy the gentle waves at Shell Point Beach. This serene location is perfect for sunbathing, beachcombing, or simply soaking in the picturesque coastal views. Bring your favorite book and unwind as you listen to the soothing sounds of the surf.
  • Wakulla Springs State Parkopens in new window – Discover the natural beauty of Wakulla Springs State Park, where crystal-clear waters invite you to cool off. Explore the lush surroundings on scenic trails or take a leisurely boat tour to spot wildlife like manatees and birds. It’s a fantastic place for a family picnic or a day of hiking.
  • St. Marks National Wildlife Refugeopens in new window – Venture into St. Marks National Wildlife Refuge, a haven for birdwatchers and nature enthusiasts. With miles of trails and diverse habitats, you can observe a wide variety of wildlife and enjoy the natural beauty of the area. Don’t miss the chance to visit the historic lighthouse!
  • Alligator Point Beachopens in new window – Experience the tranquil atmosphere of Alligator Point Beach, where you can stroll along the shoreline or enjoy a peaceful day of fishing. The unspoiled landscape offers stunning sunsets and a perfect backdrop for relaxation away from the crowds.
  • Bald Point State Parkopens in new window – Explore the diverse ecosystems at Bald Point State Park, where marshes meet the Gulf of Mexico. Hike through the trails and take in the breathtaking views or spot a variety of birds. It’s an ideal spot for outdoor enthusiasts looking to connect with nature.

4 tips for savvy savings when booking a hotel in Panacea

  1. Book for the cheapest times: The most affordable time to visit Panacea is during January, July, and December, when hotel prices tend to be lower. For those looking to explore the area's key landmarks, cultural sites, and natural wonders, a stay of at least 2 to 3 days is recommended. Visitors can enjoy beach outings, spot dolphins, indulge in fresh seafood, and unwind in secluded spots while taking in breathtaking sunsets. This budget-friendly experience offers great value for money, especially for those seeking a mix of relaxation and adventure in nature, including fishing and wildlife observation.
  2. Look for last-minute deals on Hotels.com: At Panacea, you may discover a hotel deal by exploring the Deals or Last-Minute Dealsopens in new window section on Hotels.com, where discounted hotels close to your travel date could be found. You're more likely to see flash sales and special promotions if you enable email alerts or push notifications. Additionally, the Smart Shopping tool in the app helps travelers compare hotel prices and amenities, ensuring you're updated on available rooms and potential price drops for the best deal at Panacea hotels.
  3. Be flexible with dates: Prices can fluctuate based on various factors, including the hotel's location, star rating, and the time of year. Being flexible with your travel dates may help you find a better deal on your stay at the Panacea hotel. For travelers seeking something distinctive, boutique hotels often provide a more personalized experience and can sometimes offer better value. When you book through Hotels.com, we’ll inform you whether the price for your chosen dates is above or below the average. If the price seems a bit high, we’ll suggest alternative dates that might be more affordable, helping you to potentially find a better deal.
  4. Consider your location: Staying close to major attractions or city centers provides convenience, but it usually comes at a higher cost. For more affordable rates, consider hotels in less central areas or neighborhoods, striking a balance between price and accessibility to your desired destinations. You might also check out independent hotels located further out, which are more likely to offer a genuine and budget-friendly experience.

Best time to go to Panacea

Panacea experiences its lowest average temperature in January, at 53.6°F (12.0°C), while July to August are the hottest months, with an average temperature of 81.7°F (27.6°C). August tends to be the wettest month. The peak travel months to visit Panacea are April, June, and July, which see a higher number of tourists. During this peak period, the weather is mostly sunny, accompanied by light to moderate rainfall. In contrast, October to December are ideal if you're looking for a calmer vacation, marked by light rainfall and mostly sunny conditions.

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